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Sauder KA et al. Effects of pistachios on the lipid/lipoprotein profile, glycemic control, inflammation, and endothelial function in type 2 diabetes: A randomized trial. Metabolism. 2015 Nov;64(11):1521-9.
OBJECTIVE: The health benefits of regular nut consumption have been well-documented; however, effects on cardiovascular risk in diabetes are emerging. This study examined the effects of daily pistachio consumption on the lipid/lipoprotein profile, glycemic control, markers of inflammation, and endothelial function in adults with type 2 diabetes.
MATERIALS/METHODS: We enrolled 30 adults (40-74years) with well-controlled type 2 diabetes (mean glycated hemoglobin 6.2%) in a randomized, crossover, controlled feeding study. After a 2-week run-in period, participants consumed nutritionally-adequate diets with pistachios (contributing 20% of total energy) or without pistachios for 4weeks each, separated by a 2-week washout. We assessed fasting lipids/lipoproteins, glycemic measures (while fasted and during a 75g oral glucose tolerance test), inflammatory markers, and endothelial function after each diet period.
RESULTS: Total cholesterol and the ratio of total to HDL cholesterol were significantly lower (p<0.05) following the pistachio diet (4.00mmol/L and 4.06mmol/L, respectively) compared to the control diet (4.15mmol/L and 4.37mmol/L, respectively). Triglycerides were significantly lower (p=0.003) following the pistachio diet (1.56mmol/L) compared to the control diet (1.84mmol/L). There were no treatment differences in fasting glucose and insulin, but fructosamine was significantly lower (p=0.03) following the pistachio diet (228.5μmol/l) compared to the control diet (233.5μmol/l). Inflammatory markers and endothelial function were unchanged.
CONCLUSION: Daily pistachio consumption can improve some cardiometabolic risk factors in adults with well-controlled type 2 diabetes. Our findings support recommendations that individuals with diabetes follow healthy dietary patterns that include nuts.